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Recombinant Human IL-18BP protein (His Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

C-6*His

生物活性

未测试

Cat no : Eg1147

Print datasheet

Synonyms

IL18BP, IL 18BP, IL-18BP, IL18BPa, interleukin 18 binding protein

验证数据展示

  • Purity of Recombinant Human IL-18BP was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-18BP was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human IL-18BP protein Thr31-Gly194 (Accession# O95998-2) with a His tag at the C-terminus.
基因ID 10068
蛋白编号 O95998-2
预测分子量 18.4 kDa
SDS-PAGE 30-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

IL-18 binding protein (IL-18BP) is a natural regulatory molecule of the proinflammatory cytokine IL-18. IL-18BP gene is expressed in numerous types of tissues and cells of humans and animals and its expression is regulated by interferon gamma (IFN-gamma). It’s a glycoprotein belonging to the immune globulin superfamily. IL-18BP can effectively inhibit action of IL-18 in vivo and in vitro and is considered as a natural antagonist of IL-18. The imbalance of IL-18/IL-18BP has been noticed in some inflammatory diseases, including rheumatoid arthritis (RA), psoriasis, asthma, lupus erythematosus, multiple sclerosis, atherosclerosis, inflammatory bowel disease (IBD), Crohn’s disease (CD) and so on.

参考文献:

1.Wang F.(2024). Biomed Rep. 9;20(6):87.
2.Muhl H, et al.(2000). Biochem Biophys Res Commun. 267:960–963. 
3.Mazodier K, et al.(2005). Blood. 106:3483–3489.
4.Mochol M, et al.(2020). 80:221–225. 
5.Park SY, et al.(2022). 10(7):1750.