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验证数据展示

  • WB analysis using 86799-1-RR (same clone as 86799-1-PBS)

    WB analysis using 86799-1-RR (same clone as 86799-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86799-1-RR (UPK1A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86799-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse bladder using 86799-1-RR (same clone as 86799-1-PBS)

    IF Staining of mouse bladder using 86799-1-RR (same clone as 86799-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse bladder tissue using UPK1A antibody (86799-1-RR, Clone: 251472C10 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86799-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86799-1-RR

    Affinity and Kinetic Characterization of 86799-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86799-1-RR against Human UPK1A were performed. The affinity constant is below 1 pM.

UPK1A Recombinant monoclonal antibody, PBS Only

UPK1A Uni-rAb® Recombinant Antibody for WB, IF-P, Indirect ELISA
Cat No. 86799-1-PBS

产品说明书

CloneNo. 251472C10

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF-P, Indirect ELISA

别名

TSPAN21, Tetraspanin-21, Tspan-21, UP1a, UPIa

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy UPK1A Ready-To-Use IHC Kit. UPK1A primary antibody included.

产品信息

86799-1-PBS targets UPK1A in WB, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag17356

Product name: Recombinant human UPK1A protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 111-230 aa of BC107098

Sequence: CITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQELTRLWDRVMIEQECCGTSGPMDWVNFTSAFRAATPEVVFPWPPLCCRRTGNFIPLNEEGCRLGHMDYLFTKGCFEHIGHAIDSYT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 uroplakin 1A
别名 TSPAN21, Tetraspanin-21, Tspan-21, UP1a, UPIa
计算分子量 258 aa, 29 kDa
观测分子量 29 kDa
GenBank蛋白编号BC107098
基因名称 UPK1A
Gene ID (NCBI) 11045
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO00322
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin-1a (UPK1A) belongs to the tetraspanin (TM4SF) family. UPK1A plays an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane.

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