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验证数据展示

  • IHC staining of mouse testis using 30112-1-AP (same clone as 30112-1-PBS)

    IHC staining of mouse testis using 30112-1-AP (same clone as 30112-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 30112-1-AP (TTC21B antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30112-1-PBS in a different storage buffer formulation.

  • WB analysis using 30112-1-AP (same clone as 30112-1-PBS)

    WB analysis using 30112-1-AP (same clone as 30112-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30112-1-AP (TTC21B antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30112-1-PBS in a different storage buffer formulation.

TTC21B Polyclonal antibody, PBS Only

TTC21B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 30112-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

30112-1-PBS targets TTC21B in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag32456

Product name: Recombinant human TTC21B protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 149-462 aa of NM_024753

Sequence: AWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQ*

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 tetratricopeptide repeat domain 21B
别名
计算分子量151KD
观测分子量 55 kDa
GenBank蛋白编号NM_024753
基因名称 TTC21B
Gene ID (NCBI) 79809
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ7Z4L5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TTC21B, also known as THM1, IFT139, belongs to the TTC21 family, containing several tetratricopeptide repeat (TPR) domains. TTC21B is a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). TTC21B is essential for retrograde trafficking of IFT-1, IFT-B, and GPCRs (PubMed:27932497). TTC21B is localized to the cilium axoneme and may play a role in retrograde intraflagellar transport in cilia (PMID: 18327258). Mutations in TTC21B are associated with nephronophthisis 12 (NPHP12)and short-rib thoracic dysplasia 4 with or without polydactyly (SRTD4)(PMID: 21258341).

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