验证数据展示
产品信息
83767-1-PBS targets TNC/Tenascin-C in WB, IHC, Cytometric bead array, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IHC, Cytometric bead array, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | TNC/Tenascin-C fusion protein Ag27122 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | tenascin C |
别名 | Tenascin, TNC, 240844A2, Glioma-associated-extracellular matrix antigen, GMEM |
计算分子量 | 2201 aa, 241 kDa |
观测分子量 | 220-350 kDa, 190-240 kDa |
GenBank蛋白编号 | BC151843 |
基因名称 | Tenascin C |
Gene ID (NCBI) | 3371 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P24821 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Tenascin-C (TNC) is a large hexameric extracellular matrix glycoprotein of the tenascin family (PMID: 21818551). It is a multimodular protein containing multiple epidermal growth factor (EGF)-like repeats and fibronectin type III (FN III) domains (PMID: 1719530). Tenascin-C is highly expressed during embryonic development, particularly in the developing central nervous system, around motile cells and at epithelial-mesenchymal interaction sites (PMID: 25738825). In adult tissues, the expression and the distribution of TNC are typically limited under normal physiological conditions. It is upregulated during injury, inflammation, regeneration, and cancer (PMID: 7694605; 25120494). Tenascin-C is a diverse protein that can produce different functions including regulating cell adhesion, migration and proliferation.