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验证数据展示

  • IHC staining of human thyroid cancer using 10480-1-AP (same clone as 10480-1-PBS)

    IHC staining of human thyroid cancer using 10480-1-AP (same clone as 10480-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 10480-1-AP (Prothymosin Alpha antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10480-1-PBS in a different storage buffer formulation.

  • IHC staining of rat colon using 10480-1-AP (same clone as 10480-1-PBS)

    IHC staining of rat colon using 10480-1-AP (same clone as 10480-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat colon tissue slide using 10480-1-AP (Prothymosin Alpha antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10480-1-PBS in a different storage buffer formulation.

Prothymosin Alpha Polyclonal antibody, PBS Only

Prothymosin Alpha Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 10480-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

IHC, Indirect ELISA

别名

Prothymosin alpha, N-terminally processed, prothymosin, alpha, PTMA, Thymosin alpha-1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

10480-1-PBS targets Prothymosin Alpha in IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原 Prothymosin Alpha fusion protein Ag0732 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 prothymosin, alpha
别名 Prothymosin alpha, N-terminally processed, prothymosin, alpha, PTMA, Thymosin alpha-1
计算分子量 12 kDa
GenBank蛋白编号BC003510
基因名称 Prothymosin Alpha/PTMA
Gene ID (NCBI) 5757
RRIDAB_2174388
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP06454
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Prothymosin alpha (PTMA) is a nuclear protein possessing a number of cellular functions including cell survival. PTMA is identified to be localized in the nuclei of neurons, while it is found in both nuclei and cytoplasm in the astrocytes and microglia of adult brai. PTMA inhibits the neuronal necrosis induced by serum-free starvation or ischemia-reperfusion stress, which causes a rapid internalization of GLUT1/4, leading a decrease in glucose uptake and cellular ATP levels. Extensive research on PTMA showed that it is of clinical significance and potential medical use as they may serve as a molecular marker for cancer prognosis and/or as therapeutic agents for treating immunodeficiencies, autoimmune diseases and malignancies.