验证数据展示
Planning an IHC experiment? We recommend our IHCeasy LYN Ready-To-Use IHC Kit. LYN primary antibody included.
产品信息
86947-2-PBS targets Phospho-LYN (Tyr508) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog |
| 别名 | LYN, EC:2.7.10.2, JTK8, Lck/Yes-related novel protein tyrosine kinase, Tyrosine protein kinase Lyn |
| 计算分子量 | 512 aa, 59 kDa |
| 观测分子量 | 53 kDa, 56 kDa |
| GenBank蛋白编号 | BC075002 |
| 基因名称 | LYN |
| Gene ID (NCBI) | 4067 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P07948 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
LYN, also named as JTK8, p53Lyn and p56Lyn, belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. The C-terminal tyrosine-508 residue (Tyr-508) in Lyn or the corresponding conserved tyrosine residue in each of the other members of the SFK family is the primary site for regulating tyrosine kinase activity by reversible phosphorylation. Phosphorylation at the tyrosine residue induces a closed conformation that is enzymatically inactive. (PMID: 33004926)
