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验证数据展示

  • WB analysis of pig spleen using 68635-1-Ig (same clone as 68635-1-PBS)

    WB analysis of pig spleen using 68635-1-Ig (same clone as 68635-1-PBS)

    pig spleen tissue were subjected to SDS PAGE followed by western blot with 68635-1-Ig (PTPRH antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68635-1-PBS in a different storage buffer formulation.

  • WB analysis of A431 using 68635-1-Ig (same clone as 68635-1-PBS)

    WB analysis of A431 using 68635-1-Ig (same clone as 68635-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 68635-1-Ig (PTPRH antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68635-1-PBS in a different storage buffer formulation.

PTPRH Monoclonal antibody, PBS Only

PTPRH Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68635-1-PBS

产品说明书

CloneNo. 3C6E8

宿主/亚型

Mouse / IgG1

种属反应性

human, pig

应用

WB, Indirect ELISA

别名

SAP1, SAP 1, R PTP H, 3C6E8

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

68635-1-PBS targets PTPRH in WB, Indirect ELISA applications and shows reactivity with human, pig samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, pig
免疫原 PTPRH fusion protein Ag17351 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 protein tyrosine phosphatase, receptor type, H
别名 SAP1, SAP 1, R PTP H, 3C6E8
计算分子量 1115 aa, 122 kDa
观测分子量200-210 kDa
GenBank蛋白编号BC111716
基因名称 PTPRH
Gene ID (NCBI) 5794
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ9HD43
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PTPRH, also known as SAP-1 (Stomach Cancer-Associated Protein-Tyrosine Phosphatase-1), is a member of the protein tyrosine phosphatase (PTP) family. These enzymes regulate cellular signaling by dephosphorylating tyrosine residues on proteins, counterbalancing kinase activity (PMID: 11278335). PTPRH is classified as a receptor-type PTP, characterized by an extracellular domain, a transmembrane region, and intracellular catalytic domains. In colorectal, gastric, and hepatocellular cancers, PTPRH is often upregulated and linked to poor prognosis (PMID: 12101188). Paradoxically, it may suppress tumorigenesis in other contexts by stabilizing cell adhesion. Overexpression in certain cancers suggests utility as a diagnostic or prognostic marker. The molecular weight of PTPRH is 122 kDa, it is reported that it can form a dimer with a molecular weight of 210 kDa (PMID:15850787).