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验证数据展示

  • WB analysis using 29424-1-AP (same clone as 29424-1-PBS)

    WB analysis using 29424-1-AP (same clone as 29424-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29424-1-AP (PPP1R3C antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 29424-1-AP (PPP1R3C antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    IHC staining of human colon cancer using 29424-1-AP (same clone as 29424-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 29424-1-AP (PPP1R3C antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29424-1-PBS in a different storage buffer formulation.

PPP1R3C Polyclonal antibody, PBS Only

PPP1R3C Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 29424-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

PP1 subunit R5, PPP1R5, Protein targeting to glycogen

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

29424-1-PBS targets PPP1R3C in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag30280

Product name: Recombinant human PPP1R3C protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 42-185 aa of BC012625

Sequence: PYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein phosphatase 1, regulatory (inhibitor) subunit 3C
别名 PP1 subunit R5, PPP1R5, Protein targeting to glycogen
计算分子量 317 aa, 36 kDa
观测分子量36 kDa
GenBank蛋白编号BC012625
基因名称 PPP1R3C
Gene ID (NCBI) 5507
RRIDAB_2918304
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9UQK1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

• Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) is an enzyme that binds to protein phosphatase-1 (PP1) as a regulator. The central role of PPP1R3C is associated with glycogenesis and the overexpression of this gene increases glycogen storage. The cellular glycogen level is suppressed when PPP1R3C is knocked-down. PPP1R3C induces glycogen accumulation via HIF1 α during hypoxia and it is hypermethylated in melanoma (PMID: 25846879). Overexpression of PPP1R3C increased hepatic gluconeogenesis in vitro and in vivo while knockdown of PPP1R3C showed an opposite result (PMID: 31181215).

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