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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
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Conjugate
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验证数据展示

  • IHC staining of human colon using 21370-1-AP (same clone as 21370-1-PBS)

    IHC staining of human colon using 21370-1-AP (same clone as 21370-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 21370-1-AP (PLCB3 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 21370-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 21370-1-AP (same clone as 21370-1-PBS)

    IHC staining of human colon using 21370-1-AP (same clone as 21370-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 21370-1-AP (PLCB3 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 21370-1-PBS in a different storage buffer formulation.

  • WB analysis of MCF-7 using 21370-1-AP (same clone as 21370-1-PBS)

    WB analysis of MCF-7 using 21370-1-AP (same clone as 21370-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 21370-1-AP (PLCB3 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21370-1-PBS in a different storage buffer formulation.

PLCB3 Polyclonal antibody, PBS Only

PLCB3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 21370-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, EC:3.1.4.11, Phosphoinositide phospholipase C-beta-3, Phospholipase C beta 3, Phospholipase C-beta-3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21370-1-PBS targets PLCB3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 PLCB3 fusion protein Ag15845 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 phospholipase C, beta 3 (phosphatidylinositol-specific)
别名 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, EC:3.1.4.11, Phosphoinositide phospholipase C-beta-3, Phospholipase C beta 3, Phospholipase C-beta-3
计算分子量 1234 aa, 139 kDa
观测分子量 150 kDa
GenBank蛋白编号BC142681
基因名称 PLCB3
Gene ID (NCBI) 5331
RRIDAB_2878848
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ01970
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PLCB3 is a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Six subfamilies of PLCs (B, G, D, E, Z and H) constitute part of ubiquitous signaling cascades that translate hormonal signals into intracellular events, leading to alternations in cell function. PLCB isoforms 1-4 are stimulated by G-protein activation (Gαq/11 and/or Gβγ). Independent of its enzymatic activity, PLCB3 inhibits the proliferation of hematopoietic stem cells (HSCs) and myeloid cells.