验证数据展示
发表文章中的应用
| IF | See 1 publications below |
产品信息
21384-1-AP targets PAX8 in IF, ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | IF |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse |
| 免疫原 | PAX8 fusion protein Ag16019 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | paired box 8 |
| 别名 | paired box 8, Paired box protein Pax 8, PAX 8, PAX8 |
| 计算分子量 | 450 aa, 48 kDa |
| GenBank蛋白编号 | BC001060 |
| 基因名称 | PAX8 |
| Gene ID (NCBI) | 7849 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q06710 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. PAX8 can be used in a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. Mutation of PAX8 will cause congenital hypothyroidism non-goitrous type 2 (CHNG2). This antibody is specific to Pax8.
发表文章
| Species | Application | Title |
|---|---|---|
Sci Rep Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. | ||
Cell Rep Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis. |