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验证数据展示

  • WB analysis using 11001-1-AP (same clone as 11001-1-PBS)

    WB analysis using 11001-1-AP (same clone as 11001-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11001-1-AP (PANK2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11001-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 11001-1-AP (same clone as 11001-1-PBS)

    IP experiment of mouse brain using 11001-1-AP (same clone as 11001-1-PBS)

    IP result of anti-PANK2 (IP:11001-1-AP, 3ug; Detection:11001-1-AP 1:800) with mouse brain tissue lysate 9500ug. This data was developed using the same antibody clone with 11001-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 11001-1-AP (same clone as 11001-1-PBS)

    IHC staining of human lung cancer using 11001-1-AP (same clone as 11001-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer using 11001-1-AP (PANK2 antibody) at dilution of 1:10 (under 10x lens). This data was developed using the same antibody clone with 11001-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 11001-1-AP (same clone as 11001-1-PBS)

    IF Staining of HepG2 using 11001-1-AP (same clone as 11001-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using PANK2 antibody (11001-1-AP) at dilution of 1:200 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002), CL594-phalloidin (red). This data was developed using the same antibody clone with 11001-1-PBS in a different storage buffer formulation.

PANK2 Polyclonal antibody, PBS Only

PANK2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 11001-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

Pantothenate kinase 2, mitochondrial intermediate form, mPanK2, iPanK2, hPanK2, EC:2.7.1.33

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

11001-1-PBS targets PANK2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag1413

Product name: Recombinant human PANK2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 328-570 aa of BC009421

Sequence: IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKRVTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGDYERFGLPGWAVASSFGNMMSKEKREAVSKEDLARATLITITNNIGSIARMCALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYFGAVGALLELLKIP

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 pantothenate kinase 2
别名 Pantothenate kinase 2, mitochondrial intermediate form, mPanK2, iPanK2, hPanK2, EC:2.7.1.33
计算分子量 63 kDa
观测分子量63-70 kDa
GenBank蛋白编号BC009421
基因名称 PANK2
Gene ID (NCBI) 80025
RRIDAB_2159041
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BZ23
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Pantothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis. PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other abnormalities(PMID:20603201). PanK2 protein is localized to mitochondria of neurons in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-targeting sequences(PMID:15659606 ). It has 4 isoforms produced by alternative splicing and alternative initiation.

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