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验证数据展示

  • WB analysis using 17962-1-AP (same clone as 17962-1-PBS)

    WB analysis using 17962-1-AP (same clone as 17962-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17962-1-AP (OPCML antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17962-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 17962-1-AP (same clone as 17962-1-PBS)

    IHC staining of rat brain using 17962-1-AP (same clone as 17962-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 17962-1-AP (OPCML antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17962-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 17962-1-AP (same clone as 17962-1-PBS)

    IHC staining of rat brain using 17962-1-AP (same clone as 17962-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 17962-1-AP (OPCML antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17962-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 17962-1-AP (same clone as 17962-1-PBS)

    IF Staining of mouse brain using 17962-1-AP (same clone as 17962-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using OPCML antibody (17962-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17962-1-PBS in a different storage buffer formulation.

OPCML Polyclonal antibody, PBS Only

OPCML Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 17962-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF-P, Indirect ELISA

别名

IgLON family member 1, IGLON1, OBCAM, Opioid-binding cell adhesion molecule, Opioid-binding protein/cell adhesion molecule

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

17962-1-PBS targets OPCML in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag12560

Product name: Recombinant human OPCML protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 27-345 aa of BC074773

Sequence: TGVPVRSGDATFPKAMDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSGTLLAHFFIKF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 opioid binding protein/cell adhesion molecule-like
别名 IgLON family member 1, IGLON1, OBCAM, Opioid-binding cell adhesion molecule, Opioid-binding protein/cell adhesion molecule
计算分子量 345 aa, 38 kDa
观测分子量45 kDa
GenBank蛋白编号BC074773
基因名称 OPCML
Gene ID (NCBI) 4978
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ14982
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

OPCML, also called opioid-binding cell adhesion molecule (OBCAM), belongs to the IgLON limbic system-associated membrane protein (LSAMP, OPCML/OBCAM, neurotrimin) family of IgG domain containing glycosylphosphatidylinositol-anchored cell adhesion molecules. Originally isolated from brain, OPCMLis also expressed in stomach, ovary, heart, placenta, testis, kidney, liver, pancreas and colon. OPCML has been identified as a tumour suppressor, which inhibited tumor growth in some cancers including ovarian cancer, lung cancer and prostate cancer (PMID: 19176311; 28407749).

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