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Neohesperidin Dihydrochalcone

Neohesperidin Dihydrochalcone (Neohesperidin DC) 是一种合成的糖苷查耳酮，可用作低热量人造甜味剂，添加到各种食品和饮料中。

CAS号

20702-77-6

分子式

C28H36O15

主要靶点

Reactive Oxygen Species

仅限科研使用

Cat No : CM00394

Print datasheet

Synonyms

新橙皮苷二氢查耳酮|Neohesperidin DC|新橙皮苷二氢查尔酮|NHDC|NCI-c60764

验证数据展示

  • CAS No.: 20702-77-6

    Neohesperidin Dihydrochalcone
    CAS#: 20702-77-6

产品信息

Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus.

CAS号 20702-77-6
分子式 C28H36O15
主要靶点 Reactive Oxygen Species
主要通路 NF-κB信号通路|代谢|免疫与炎症
分子量 612.58
纯度 99.40%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 新橙皮苷二氢查耳酮|Neohesperidin DC|新橙皮苷二氢查尔酮|NHDC|NCI-c60764

体内活性

Neohesperidin dihydrochalcone administration causes a significant reduction in the activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone[3]. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day[4].

溶解度

Ethanol:100 mg/mL (163.24 mM),H2O:<1 mg/mL,DMSO:100 mg/mL (163.24 mM)

细胞实验

WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].

参考文献

1.Kroeze JH, Chem Senses, 2000, 25(5), 555-559.
2.Winnig M, et al. BMC Struct Biol, 2007, 7, 66.
3.Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9.
4.Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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