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Neohesperidin Dihydrochalcone

CAS号

20702-77-6

分子式

C28H36O15

主要靶点

Reactive Oxygen Species

仅限科研使用

Cat No : CM00394

Print datasheet

Synonyms

NCI-c60764|Neohesperidin DC|Neohesperidin Dihydrochalcone|NHDC|ReactiveOxygenSpecies|Reactive Oxygen Species|Inhibitor|inhibit|新橙皮苷二氢查尔酮|新橙皮苷二氢查耳酮

验证数据展示

  • CAS No.: 20702-77-6

    Neohesperidin Dihydrochalcone
    CAS#: 20702-77-6

产品信息

CAS号 20702-77-6
分子式 C28H36O15
主要靶点 Reactive Oxygen Species
主要通路 代谢|NF-κB 信号通路|免疫与炎症
分子量 612.58
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 NCI-c60764|Neohesperidin DC|Neohesperidin Dihydrochalcone|NHDC|ReactiveOxygenSpecies|Reactive Oxygen Species|Inhibitor|inhibit|新橙皮苷二氢查尔酮|新橙皮苷二氢查耳酮

体内活性

Neohesperidin dihydrochalcone的给药显著减少了肝损伤的两种有用标志物AST和ALT的活性。在PQ处理的小鼠中，NF-κB、IL-6、IL-1β和TNF-α蛋白的相对水平受到Neohesperidin dihydrochalcone的抑制[3]。对Wistar Crl:(WI)WU BR大鼠进行的Neohesperidin dihydrochalcone的胚胎毒性/致畸性研究显示，在最高剂量水平下饮食中Neohesperidin dihydrochalcone含量高达5%，相当于大鼠每日约摄入3.3 g/kg体重，未观察到不良影响[4]。

溶解度

DMSO:50 mg/mL (81.62 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:100 mg/mL (163.24 mM)

细胞实验

WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1].

参考文献

1.Kroeze JH, Chem Senses, 2000, 25(5), 555-559.
2.Winnig M, et al. BMC Struct Biol, 2007, 7, 66.
3.Shi Q, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015 Dec;29(2):722-9.
4.Waalkens-Berendsen DH, et al. Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. Regul Toxicol Pharmacol. 2004 Aug;40(1):74-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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