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验证数据展示

  • IP experiment of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    IP experiment of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    IP result of anti-NEURL (IP:18898-1-AP, 4ug; Detection:18898-1-AP 1:600) with mouse brain tissue lysate 2560ug. This data was developed using the same antibody clone with 18898-1-PBS in a different storage buffer formulation.

  • WB analysis using 18898-1-AP (same clone as 18898-1-PBS)

    WB analysis using 18898-1-AP (same clone as 18898-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18898-1-AP (NEURL antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18898-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    IHC staining of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18898-1-AP (NEURL antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18898-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    IHC staining of mouse brain using 18898-1-AP (same clone as 18898-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 18898-1-AP (NEURL antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18898-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 18898-1-AP (same clone as 18898-1-PBS)

    IF Staining of MCF-7 using 18898-1-AP (same clone as 18898-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using NEURL antibody (18898-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18898-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

NEURL Polyclonal antibody, PBS Only

NEURL Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 18898-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

neu, h-neuralized 1, h neuralized 1, h neu, EC:2.3.2.27

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

18898-1-PBS targets NEURL in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag13531

Product name: Recombinant human NEURL protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-345 aa of BC026336

Sequence: MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPAAPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAASCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 neuralized homolog (Drosophila)
别名 neu, h-neuralized 1, h neuralized 1, h neu, EC:2.3.2.27
计算分子量 59 kDa
观测分子量 60-62 kDa
GenBank蛋白编号BC026336
基因名称 NEURL
Gene ID (NCBI) 9148
RRIDAB_10642557
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO76050
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NEURL(Neuralized-like protein 1A) is also named as NEURL1, NEURL1A, RNF67.Neurl1 is a RING-dependent E3 ubiquitin ligase that can regulate Notch signaling in mammals and it expression promotes lysosomal degradation of Jagged1 in cells and blocks signaling from Jagged1-expressing cells to neighboring Notch-expressing cells. Neurl-dependent turnover of Jagged1 and inhibition of Notch signaling depends upon N-terminal myristoylation and plasma membrane localization of Neurl1(PMID:18077452).This antibody is specific to NEURL.

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