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Recombinant Mouse L1cam protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3022

Print datasheet

Synonyms

L1cam, N-CAM-L1, CAML1, CD171, N CAM L1

验证数据展示

  • Purity of Recombinant Mouse L1cam was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse L1cam was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse L1cam protein Ile20-Glu1123 (Accession# P11627) with a rabbit IgG Fc tag at the C-terminus.
基因ID 16728
蛋白编号 P11627
预测分子量 150.1 kDa
SDS-PAGE 140-250 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

L1cam (the L1 cell adhesion molecule), is the prototype member of the L1-family of closely related neural adhesion molecules. L1cam is a 200–220 kDa transmembrane glycoprotein of the immunoglobulin (Ig) superfamily composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail. L1cam plays an essential role in the development of the nervous system but it is also highly relevant for the progression of human tumors. L1cam is not expressed in most normal tissues during homeostasis, including in rapidly proliferating tissues such as the intestinal epithelium.

参考文献:

1. Doberstein K, et al. (2015). Mar 1;136(5):E326-39. 
2. Kiefel H, et al. (2012). Cell Adh Migr. Jul-Aug;6(4):374-384.
3. Ganesh K, et al. (2020). Nat Cancer. 2020 Jan;1(1):28-45.