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ML-SA1

ML-SA1 (Mucolipin synthetic agonist 1) 是一种选择性的TRPML 激动剂，通过促进溶酶体的酸化和蛋白酶活性抑制登格病毒 2 和寨卡病毒，抗 DENV2 RNA 和 ZIKV RNA 的IC50分别为 8.3 μM 和 52.99 μM。ML SA1可诱发自噬。ML SA1可用于广谱抗病毒研究。

CAS号

332382-54-4

分子式

C22H22N2O3

主要靶点

Others|TRP/TRPV Channel

仅限科研使用

Cat No : CM06793

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Synonyms

Mucolipin synthetic agonist 1

验证数据展示

  • CAS No.: 332382-54-4

    ML-SA1
    CAS#: 332382-54-4

产品信息

ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].

CAS号 332382-54-4
分子式 C22H22N2O3
主要靶点 Others|TRP/TRPV Channel
主要通路 离子通道|其他
分子量 362.42
纯度 99.28%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Mucolipin synthetic agonist 1

靶点活性

ZIKV:52.99 μM (IC50)|DENV2:8.3 μM (IC50)

体外活性

ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1]. ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1].

溶解度

DMSO:17 mg/mL (46.90 mM)

参考文献

1.Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

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