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ML-SA1

CAS号

332382-54-4

分子式

C22H22N2O3

主要靶点

Others|TRP/TRPV Channel

仅限科研使用

Cat No : CM06793

Print datasheet

Synonyms

antiviral|acidification|autophagy|broad-spectrum|inhibit|Dengue|Zika|virus|Transient receptor potential channels|TRP Channel|TRPVChannel|TRPChannel|TRPV Channel|TRPML|selective|protease|Inhibitor|MLSA1|ML-SA1|ML-SA-1|ML SA1|Mucolipin synthetic agonist 1|lysosomal

验证数据展示

  • CAS No.: 332382-54-4

    ML-SA1
    CAS#: 332382-54-4

产品信息

CAS号 332382-54-4
分子式 C22H22N2O3
主要靶点 Others|TRP/TRPV Channel
主要通路 离子通道
分子量 362.42
纯度 99.28%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 antiviral|acidification|autophagy|broad-spectrum|inhibit|Dengue|Zika|virus|Transient receptor potential channels|TRP Channel|TRPVChannel|TRPChannel|TRPV Channel|TRPML|selective|protease|Inhibitor|MLSA1|ML-SA1|ML-SA-1|ML SA1|Mucolipin synthetic agonist 1|lysosomal

靶点活性

ZIKV:52.99 μM (IC50)|DENV-2:8.3 μM (IC50)

体外活性

ML-SA1（25 μM；0~14小时；A549细胞）可能影响DENV2进入宿主细胞的过程[1]。在0至200 μM浓度范围内，ML-SA1对A549细胞线没有观察到细胞毒性，即使在高达200 μM的浓度下也是如此。ML-SA1（0~50 μM; A549细胞）显著抑制了DENV2的RNA水平，其IC50为8.93 μM[1]。在RNA和蛋白质水平上，ML-SA1对A549细胞中ZIKV的减少呈剂量依赖性，针对ZIKV RNA的IC50值为52.99 μM。作为TRPMLs的激活剂，ML-SA1在体外对DENV2和ZIKV显示出强大的抑制效果。ML-SA1通过促进溶酶体酸化和蛋白酶活性来抑制病毒感染。在Huh7细胞或A549细胞中，ML-SA1能够诱导自噬[1]。

溶解度

DMSO:17 mg/mL (46.91 mM)

参考文献

1.Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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