验证数据展示
产品信息
27543-1-PBS targets Livin in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | Livin fusion protein Ag26737 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | baculoviral IAP repeat-containing 7 |
别名 | |
计算分子量 | 33 kDa |
观测分子量 | 33 kDa |
GenBank蛋白编号 | BC014475 |
基因名称 | Livin |
Gene ID (NCBI) | 79444 |
RRID | AB_2880901 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q96CA5 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
BIRC7 also known as Livin, is one of the family members of the inhibitor of apoptosis protein (IAP). BIRC7 contains a BIR domain that has been shown to bind and inhibit caspases-3, −7 and −9, playing a key role in inhibiting apoptosis. Overexpression of BIRC7 in tumors has been linked with increased chemo- and radio-resistance, recurrence, and decreased patient survival. BIRC7 is closely associated with melanoma disease progression, apoptosis resistance, and chemotherapeutic drug resistance.