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Species Reactivity
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Species Reactivity
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验证数据展示

  • IP experiment of mouse liver using 26106-1-AP (same clone as 26106-1-PBS)

    IP experiment of mouse liver using 26106-1-AP (same clone as 26106-1-PBS)

    IP result of anti-LRP1 (IP:26106-1-AP, 4ug; Detection:26106-1-AP 1:300) with mouse liver tissue lysate 4000ug. This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

  • WB analysis using 26106-1-AP (same clone as 26106-1-PBS)

    WB analysis using 26106-1-AP (same clone as 26106-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26106-1-AP (LRP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 26106-1-AP (same clone as 26106-1-PBS)

    IHC staining of mouse brain using 26106-1-AP (same clone as 26106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26106-1-AP (LRP1 antibody) at dilution of 1:200 (under 0x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

LRP1 Polyclonal antibody, PBS Only

LRP1 Polyclonal Antibody for WB, IHC, IP, ELISA
Cat No. 26106-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, ELISA

别名

A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

26106-1-PBS targets LRP1 in WB, IHC, IP, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag23098

Product name: Recombinant human LRP1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 20-292 aa of BC045107

Sequence: AIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHLCVFSKSQQEMG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
别名 A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor
计算分子量 505 kDa
观测分子量 85-90 kDa
GenBank蛋白编号BC045107
基因名称 LRP1
Gene ID (NCBI) 4035
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ07954
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, is a multifunctional cell surface receptor that interacts through its cytoplasmic tail with adaptor and scaffold proteins that participate in cellular signaling. It is synthesized in the endoplasmic reticulum as a transmembrane glycosylated precursor that migrates with an apparent molecular mass of about 600 kd on SDS-polyacrylamide gels. After it reaches the Golgi complex, the protein is cleaved to generate two subunits with apparent molecular masses of approximately 515 and 85 kd respectively (PMID: 2112085). It involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PMID:12888553).