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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
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Compatible Species
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Conjugate
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验证数据展示

  • IP experiment of mouse liver using 26106-1-AP (same clone as 26106-1-PBS)

    IP experiment of mouse liver using 26106-1-AP (same clone as 26106-1-PBS)

    IP result of anti-LRP1 (IP:26106-1-AP, 4ug; Detection:26106-1-AP 1:300) with mouse liver tissue lysate 4000ug. This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

  • WB analysis using 26106-1-AP (same clone as 26106-1-PBS)

    WB analysis using 26106-1-AP (same clone as 26106-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26106-1-AP (LRP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 26106-1-AP (same clone as 26106-1-PBS)

    IHC staining of mouse brain using 26106-1-AP (same clone as 26106-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 26106-1-AP (LRP1 antibody) at dilution of 1:200 (under 0x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26106-1-PBS in a different storage buffer formulation.

LRP1 Polyclonal antibody, PBS Only

LRP1 Polyclonal Antibody for WB, IHC, IP, ELISA
Cat No. 26106-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, ELISA

别名

A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

26106-1-PBS targets LRP1 in WB, IHC, IP, ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, ELISA Application Description
经测试反应性 human, mouse
免疫原 LRP1 fusion protein Ag23098 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
别名 A2MR, Alpha 2 macroglobulin receptor, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor
计算分子量 505 kDa
观测分子量 85-90 kDa
GenBank蛋白编号BC045107
基因名称 LRP1
Gene ID (NCBI) 4035
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ07954
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRP1 (Prolow-density lipoprotein receptor-related protein 1), also known as A2MR, is a multifunctional cell surface receptor that interacts through its cytoplasmic tail with adaptor and scaffold proteins that participate in cellular signaling. It is synthesized in the endoplasmic reticulum as a transmembrane glycosylated precursor that migrates with an apparent molecular mass of about 600 kd on SDS-polyacrylamide gels. After it reaches the Golgi complex, the protein is cleaved to generate two subunits with apparent molecular masses of approximately 515 and 85 kd respectively (PMID: 2112085). It involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PMID:12888553).