Recombinant Human ENPEP protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human ENPEP protein Arg41-Gly957 (Accession# Q07075) with a rabbit IgG Fc tag at the C-terminus. |
基因ID | 2028 |
蛋白编号 | Q07075 |
预测分子量 | 131.1 kDa |
SDS-PAGE | 130-150 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ENPEP, or glutamyl aminopeptidase, is a type II integral membrane protein with an extracellular zinc-binding domain. ENPEP plays a significant role in the renin-angiotensin system (RAS) by participating in the catabolic pathway, forming angiotensin III from angiotensin II through the hydrolysis of the N-terminal aspartate (or glutamate), thereby regulating blood pressure and blood vessel formation. ENPEP is widely expressed in a subset of vascular smooth muscle cells, likely pericytes, in systemic vasculature, the heart, and the brain. It is expressed at high levels in the epithelial cells of the kidney glomerulus and proximal tubule cells, where it contributes to the regulation of blood pressure and may contribute to the risk of atrial fibrillation, angiogenesis, hypertension, and tumorigenesis.
参考文献:
1. Roger S Holmes. et al. (2017). J Data Mining Genomics Proteomics. 8(2):2. 2. Antti Arppo. et al.(2024). PLoS One.19(12):e0307731. 3. Aoyun Wang. et al. (2022). Cancer Med. 11(3):880-887.