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Recombinant Human ENPEP protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2736

Print datasheet

Synonyms

ENPEP, AP A, APA, AP-A, CD249

验证数据展示

  • Purity of Recombinant Human ENPEP was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ENPEP was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human ENPEP protein Arg41-Gly957 (Accession# Q07075) with a rabbit IgG Fc tag at the C-terminus.
基因ID 2028
蛋白编号 Q07075
预测分子量 131.1 kDa
SDS-PAGE 130-150 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

ENPEP, or glutamyl aminopeptidase, is a type II integral membrane protein with an extracellular zinc-binding domain. ENPEP plays a significant role in the renin-angiotensin system (RAS) by participating in the catabolic pathway, forming angiotensin III from angiotensin II through the hydrolysis of the N-terminal aspartate (or glutamate), thereby regulating blood pressure and blood vessel formation. ENPEP is widely expressed in a subset of vascular smooth muscle cells, likely pericytes, in systemic vasculature, the heart, and the brain. It is expressed at high levels in the epithelial cells of the kidney glomerulus and proximal tubule cells, where it contributes to the regulation of blood pressure and may contribute to the risk of atrial fibrillation, angiogenesis, hypertension, and tumorigenesis.

参考文献:

1. Roger S Holmes. et al. (2017). J Data Mining Genomics Proteomics. 8(2):2.
2. Antti Arppo. et al.(2024). PLoS One.19(12):e0307731.
3. Aoyun Wang. et al. (2022). Cancer Med. 11(3):880-887.