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Recombinant Human CCL20/MIP-3 alpha protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2398

Print datasheet

Synonyms

CCL20, MIP-3 Alpha, MIP-3α, Beta-chemokine exodus-1, C C motif chemokine 20

验证数据展示

  • Purity of Recombinant Human CCL20 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CCL20 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CCL20 protein Ala27-Met96 (Accession# P78556-1) with a rabbit IgG Fc tag at the N-terminus.
基因ID 6364
蛋白编号 P78556-1
预测分子量 35.2 kDa
SDS-PAGE 32-40 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CCL20, also known as MIP-3 alpha, is a chemokine expressed mainly in the lymphatic tissue, lung and liver produced by cells related with inflammation and autoimmune response such as endothelial cells, neutrophils, natural killer (NK), Th17 cells and B cells among others. CCL20 contributes to inflammatory cell recruitment. CCL20 selectively signals through its receptor CCR6. The ligand-receptor pair CCL20/CCR6 is responsible for the chemoattraction of immature dendritic cells, effector/memory T cells and B cells, and also serves a role in the skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathological processes, such as those associated with cancer and rheumatoid arthritis.

参考文献:

1. Schutyser E. et al. (2003). Cytokine Growth Factor Rev. 14(5):409-26.
2. Hromas R. et al. (1997). Blood. 89(9):3315-22.
3. Shimizu Y. et al. (2001). Hepatology. 34(2):311-9.
4. Lee AY. et al.(2013). Front Immunol. 4:194.