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验证数据展示

  • WB analysis of HeLa using 11178-1-AP (same clone as 11178-1-PBS)

    WB analysis of HeLa using 11178-1-AP (same clone as 11178-1-PBS)

    WB result of EXOSC10 antibody (11178-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-EXOSC10 transfected HeLa cells. This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • IP experiment of MCF-7 using 11178-1-AP (same clone as 11178-1-PBS)

    IP experiment of MCF-7 using 11178-1-AP (same clone as 11178-1-PBS)

    IP result of anti-EXOSC10 (IP:11178-1-AP, 4ug; Detection:11178-1-AP 1:300) with MCF-7 cells lysate 3200 ug. This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 11178-1-AP (same clone as 11178-1-PBS)

    IHC staining of human breast cancer using 11178-1-AP (same clone as 11178-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer using 11178-1-AP (EXOSC10 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with EXOSC10 antibody included
  • IF Staining of NIH/3T3 using 11178-1-AP (same clone as 11178-1-PBS)

    IF Staining of NIH/3T3 using 11178-1-AP (same clone as 11178-1-PBS)

    Immunofluorescent analysis of NIH/3T3 cells using 11178-1-AP (EXOSC10 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11178-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

EXOSC10 Polyclonal antibody, PBS Only

EXOSC10 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 11178-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy EXOSC10 Ready-To-Use IHC Kit. EXOSC10 primary antibody included.

产品信息

11178-1-PBS targets EXOSC10 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag1666

Product name: Recombinant human EXOSC10 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 586-885 aa of BC039901

Sequence: VAAGVKKSGPLPSAERLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITLFNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEISNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKRERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQFDPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 exosome component 10
别名
计算分子量 98 kDa
观测分子量100 kDa
GenBank蛋白编号BC039901
基因名称 EXOSC10
Gene ID (NCBI) 5394
RRIDAB_2293792
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ01780
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a neuclear
ucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl 2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl paitents. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

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