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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 55367-1-AP (same clone as 55367-1-PBS)

    WB analysis using 55367-1-AP (same clone as 55367-1-PBS)

    Mouse lung tissue were subjected to SDS PAGE followed by western blot with 55367-1-AP (EVC2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55367-1-PBS in a different storage buffer formulation.

  • IHC staining of human placenta using 55367-1-AP (same clone as 55367-1-PBS)

    IHC staining of human placenta using 55367-1-AP (same clone as 55367-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 55367-1-AP (EVC2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55367-1-PBS in a different storage buffer formulation.

EVC2 Polyclonal antibody, PBS Only

EVC2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 55367-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

55367-1-PBS targets EVC2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Ellis van Creveld syndrome 2
别名
计算分子量 148 kDa
观测分子量140 kDa
GenBank蛋白编号NM_147127
基因名称 EVC2
Gene ID (NCBI) 132884
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ86UK5
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

EVC2 (also known as LIMBIN) is close proximity in divergent orientation to EVC and mutations in both human genes lead to the chondrodysplasia Ellis-van Creveld (EvC) syndrome. Typical symptoms of EvC include shorter limbs and ribs, postaxial polydactyly, dysplastic nails, and cardiovascular defects (PMID: 28081373). Additionally, EvC syndrome has been characterized as a ciliopathy because the EVC and EVC2 proteins are intracellularly localized at the bottom of the primary cilium, where they form a heterotrimeric protein complex with SMO and transduce Hedgehog(Hh) signaling (PMID: 30410447). EVC2 is expressed in the heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. EVC2 has 3 isoforms with the molecular mass of 140-148 kDa.