验证数据展示
产品信息
20894-1-PBS targets E-selectin/CD62E in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | E-selectin/CD62E fusion protein Ag14944 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | selectin E |
别名 | CD62E, E-selectin, CD62 antigen-like family member E, ELAM1, ELAM 1 |
计算分子量 | 610 aa, 67 kDa |
观测分子量 | 115 kDa |
GenBank蛋白编号 | BC142711 |
基因名称 | CD62E |
Gene ID (NCBI) | 6401 |
RRID | AB_10755287 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P16581 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
E-selectin, also known as ELAM-1 or CD62E, is a member of the selectin family of adhesion molecules that also includes L-selectin and P-selectin. E-selectin is an inducible endothelial cell surface molecule. Its expression on endothelial cells is transcriptionally upregulated by various proinflammatory substances such as IL-1, TNFα and lipopolysaccharide (LPS). Besides, it can be secreted by endothelial cells, and can be detected in a soluble form (sE-selectin) in serum. During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. (PMID: 2827173; 1382417; 8943958)