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D-α-Hydroxyglutaric acid disodium

D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物，可增加活性氧的产生。它是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂，可抑制多种α-KG 依赖性双加氧酶，Ki 为 10.87 mM。

CAS号

103404-90-6

分子式

C5H6Na2O5

主要靶点

mTOR|ATPase|Endogenous Metabolite|Reactive Oxygen Species|Others

仅限科研使用

Cat No : CM00197

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Synonyms

(R)-2-羟基戊二酸二钠盐|Disodium (R)-2-Hydroxyglutarate|D-alpha-Hydroxyglutaric acid disodium salt

验证数据展示

  • CAS No.: 103404-90-6

    D-α-Hydroxyglutaric acid disodium
    CAS#: 103404-90-6

产品信息

D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.

CAS号 103404-90-6
分子式 C5H6Na2O5
主要靶点 mTOR|ATPase|Endogenous Metabolite|Reactive Oxygen Species|Others
主要通路 NF-κB信号通路|免疫与炎症|离子通道|PI3K/Akt/mTOR信号通路|代谢|其他
分子量 192.08
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (R)-2-羟基戊二酸二钠盐|Disodium (R)-2-Hydroxyglutarate|D-alpha-Hydroxyglutaric acid disodium salt

靶点活性

α-ketoglutarate-dependent dioxygenases:0.628 mM(Ki)

体外活性

In U-87 mg cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. [1] Besides, (R)-2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing. [2]

溶解度

DMSO:2.5 mM

细胞实验

Cells are seeded in 12-well plates and, after overnight incubation, treated with the indicated concentrations of each compound. After harvesting, cells are stained with acridine orange (AO) and 4′,6-diamidino-2-phenylindole (DAPI). Cell number and viability are measured based on AO and DAPI fluorescence as measured by NC3000 following the manufacturer's instructions.(Only for Reference)

参考文献

1.Xu W, et al. Cancer Cell. 2011, 19(1), 17-30.
2.Kim SY, et al. Cardiovasc Res. 2011, 92(2), 307-316.

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