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D-α-Hydroxyglutaric acid disodium

CAS号

103404-90-6

分子式

C5H6Na2O5

主要靶点

mTOR|ATPase|Endogenous Metabolite|Reactive Oxygen Species|Others

仅限科研使用

Cat No : CM00197

Print datasheet

Synonyms

competitor|CeKDM7A|ATP Synthase|5-methlycytosine|(R)-2-羟基戊二酸二钠盐|D-alpha-Hydroxyglutaric acid|D-alpha-Hydroxyglutaric acid disodium|D-alpha-Hydroxyglutaric acid disodium salt|D-a-Hydroxyglutaric acid|D-a-Hydroxyglutaric acid disodium|D α Hydroxyglutaric acid disodium|Disodium (R)-2-Hydroxyglutarate|Disodium 2-Hydroxyglutarate|D-α-Hydroxyglutaric acid|DαHydroxyglutaric acid disodium|D-α-Hydroxyglutaric acid disodium|Endogenous Metabolite|EndogenousMetabolite|excitotoxic|H3K9me2|H3K27me2|inhibit|IDH1|IDH2|α-KG|α-ketoglutarate|neurotoxic|Reactive Oxygen Species|ReactiveOxygenSpecies|Mammalian target of Rapamycin|mTOR|Inhibitor

验证数据展示

  • CAS No.: 103404-90-6

    D-α-Hydroxyglutaric acid disodium
    CAS#: 103404-90-6

产品信息

CAS号 103404-90-6
分子式 C5H6Na2O5
主要靶点 mTOR|ATPase|Endogenous Metabolite|Reactive Oxygen Species|Others
主要通路 PI3K/Akt/mTOR 信号通路|代谢|代谢|NF-κB 信号通路|免疫与炎症|离子通道
分子量 192.08
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 competitor|CeKDM7A|ATP Synthase|5-methlycytosine|(R)-2-羟基戊二酸二钠盐|D-alpha-Hydroxyglutaric acid|D-alpha-Hydroxyglutaric acid disodium|D-alpha-Hydroxyglutaric acid disodium salt|D-a-Hydroxyglutaric acid|D-a-Hydroxyglutaric acid disodium|D α Hydroxyglutaric acid disodium|Disodium (R)-2-Hydroxyglutarate|Disodium 2-Hydroxyglutarate|D-α-Hydroxyglutaric acid|DαHydroxyglutaric acid disodium|D-α-Hydroxyglutaric acid disodium|Endogenous Metabolite|EndogenousMetabolite|excitotoxic|H3K9me2|H3K27me2|inhibit|IDH1|IDH2|α-KG|α-ketoglutarate|neurotoxic|Reactive Oxygen Species|ReactiveOxygenSpecies|Mammalian target of Rapamycin|mTOR|Inhibitor

靶点活性

α-ketoglutarate-dependent dioxygenase:0.628 mM(Ki)

体外活性

在U-87 mg细胞中，D-α-Hydroxyglutaric acid disodium 作为α-KG的弱拮抗剂，通过抑制α-KG依赖的组蛋白去甲基酶，增加了H3K9和H3K79的双甲基化。[1]此外，D-α-Hydroxyglutaric acid disodium还抑制了ATP合酶和mTOR信号传导，从而导致生长停滞和肿瘤细胞死亡。[2]

溶解度

DMSO:< 1 mg/mL (insoluble）

细胞实验

Cells are seeded in 12-well plates and, after overnight incubation, treated with the indicated concentrations of each compound. After harvesting, cells are stained with acridine orange (AO) and 4′,6-diamidino-2-phenylindole (DAPI). Cell number and viability are measured based on AO and DAPI fluorescence as measured by NC3000 following the manufacturer's instructions.(Only for Reference)

参考文献

1.Xu W, et al. Cancer Cell. 2011, 19(1), 17-30.
2.Kim SY, et al. Cardiovasc Res. 2011, 92(2), 307-316.

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