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Coralyne chloride

CAS号

38989-38-7

分子式

C22H22ClNO4

主要靶点

Topoisomerase

仅限科研使用

Cat No : CM11450

Print datasheet

Synonyms

protoberberine|neurodrug|Inhibitor|氯化柯喃炔水合物|Topoisomerase|topoisomerase I|Coralyne|Coralyne Chloride|Coralyne chloride|inhibit|cancer|Antileukemic

验证数据展示

  • CAS No.: 38989-38-7

    Coralyne chloride
    CAS#: 38989-38-7

产品信息

CAS号 38989-38-7
分子式 C22H22ClNO4
主要靶点 Topoisomerase
主要通路 DNA 损伤和修复
分子量 399.87
纯度 99.35%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 protoberberine|neurodrug|Inhibitor|氯化柯喃炔水合物|Topoisomerase|topoisomerase I|Coralyne|Coralyne Chloride|Coralyne chloride|inhibit|cancer|Antileukemic

体外活性

There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line[2].

溶解度

DMSO:1.5 mg/mL (3.75 mM);H2O:3 mg/mL (7.5 mM)

参考文献

1.Khadka DB, Cho WJ. Topoisomerase inhibitors as anticancer agents: a patent update. Expert Opin Ther Pat. 2013 Aug;23(8):1033-56.
2.Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.
3.Bhadra K, Kumar GS. Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. Med Res Rev. 2011 Nov;31(6):821-62.
4.Giri P, Suresh Kumar G. Molecular recognition of poly(A) targeting by protoberberine alkaloids: in vitro biophysical studies and biological perspectives. Mol Biosyst. 2010 Jan;6(1):81-8.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2