CXCL8/IL-8 Monoclonal antibody

CXCL8/IL8 Monoclonal Antibody for ELISA
Cat No. 60141-2-Ig

产品说明书

CloneNo. 3D11D5

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

ELISA and More (2)

C X C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, IL 8, IL8, Inteleukin 8, interleukin 8

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy CXCL8/IL-8 Ready-To-Use IHC Kit. CXCL8/IL-8 primary antibody included.

产品信息

60141-2-Ig targets CXCL8/IL8 in WB, IHC, ELISA applications and shows reactivity with human samples.

经测试应用 ELISA Application Description
文献引用应用WB, IHC, ELISA
经测试反应性 human
文献引用反应性human
免疫原 CXCL8/IL8 fusion protein Ag10552 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 8
别名 C X C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, IL 8, IL8, Inteleukin 8, interleukin 8
计算分子量 99 aa, 11 kDa
GenBank蛋白编号BC013615
基因名称 IL-8
Gene ID (NCBI) 3576
ENSEMBL Gene IDENSG00000169429
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP10145
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).

发表文章

SpeciesApplicationTitle
humanWB

Aging Cell

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.

Authors - Qixia Xu
humanWB,IHC

Front Immunol

Ultraviolet B Inhibits IL-17A/TNF-α-Stimulated Activation of Human Dermal Fibroblasts by Decreasing the Expression of IL-17RA and IL-17RC on Fibroblasts.

Authors - Li Yin
humanIHC

PLoS One

Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate.

Authors - Ami Oizumi
humanIHC

Cancer Med

Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing.

Authors - Sen Wang
humanELISA

BMC Biotechnol

Expression, purification, and characterization of rhTyrRS.

Authors - Yongjiang Lang
humanWB

Oncogene

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance

Authors - Changxu Wang
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