验证数据展示
发表文章中的应用
WB | See 3 publications below |
IHC | See 3 publications below |
ELISA | See 1 publications below |
产品信息
60141-2-Ig targets CXCL8/IL8 in WB, IHC, ELISA applications and shows reactivity with human samples.
经测试应用 | ELISA Application Description |
文献引用应用 | WB, IHC, ELISA |
经测试反应性 | human |
文献引用反应性 | human |
免疫原 | CXCL8/IL8 fusion protein Ag10552 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | interleukin 8 |
别名 | C X C motif chemokine 8, CXC chemokine ligand 8, CXCL 8, CXCL8, IL 8, IL8, Inteleukin 8, interleukin 8 |
计算分子量 | 99 aa, 11 kDa |
GenBank蛋白编号 | BC013615 |
基因名称 | IL-8 |
Gene ID (NCBI) | 3576 |
ENSEMBL Gene ID | ENSG00000169429 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P10145 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).
发表文章
Species | Application | Title |
---|---|---|
Aging Cell Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. | ||
Front Immunol Ultraviolet B Inhibits IL-17A/TNF-α-Stimulated Activation of Human Dermal Fibroblasts by Decreasing the Expression of IL-17RA and IL-17RC on Fibroblasts. | ||
PLoS One Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. | ||
Cancer Med Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. | ||
Oncogene Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance |