验证数据展示
产品信息
32100-1-PBS targets C2orf69 in WB, IHC, Indirect ELISA applications and shows reactivity with mouse, rat samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | mouse, rat |
免疫原 | C2orf69 fusion protein Ag36779 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | chromosome 2 open reading frame 69 |
别名 | Chromosome 2 Open Reading Frame 69, COXPD53, FLJ38973, Hypothetical Protein FLJ38973, Mitochondrial protein C2orf69 |
计算分子量 | 43 kDa |
观测分子量 | 50 kDa |
GenBank蛋白编号 | BC036456 |
基因名称 | C2orf69 |
Gene ID (NCBI) | 205327 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity Purification |
UNIPROT ID | Q8N8R5 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Chromosome 2 open reading frame 69 (C2orf69, also known as COXPD53) is located in the mitochondrion. It can affect mitochondrial membrane potential and oxidative respiration in cultured neurons and controls the levels of the glycogen branching enzyme 1 (GBE1) (PMID: 34038740; 33945503). The variant in C2orf69 probably causes developmental regression, seizures, microcephaly, autistic features, and hypertonia (PMID: 37337918). Its deficiency can disrupt the development and homeostasis of the immune and central nervous systems (PMID: 34038740).