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验证数据展示

  • WB analysis of human skeletal muscle using 21183-1-AP (same clone as 21183-1-PBS)

    WB analysis of human skeletal muscle using 21183-1-AP (same clone as 21183-1-PBS)

    human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 21183-1-AP (C13orf18 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21183-1-PBS in a different storage buffer formulation.

  • IF Staining of U-251 using 21183-1-AP (same clone as 21183-1-PBS)

    IF Staining of U-251 using 21183-1-AP (same clone as 21183-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed U-251 cells using C13orf18 antibody (21183-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 21183-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 21183-1-AP (same clone as 21183-1-PBS)

    IHC staining of human testis using 21183-1-AP (same clone as 21183-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 21183-1-AP (C13orf18 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21183-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 21183-1-AP (same clone as 21183-1-PBS)

    IHC staining of human testis using 21183-1-AP (same clone as 21183-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis tissue slide using 21183-1-AP (C13orf18 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21183-1-PBS in a different storage buffer formulation.

C13orf18 Polyclonal antibody, PBS Only

C13orf18 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 21183-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

Pacer, Protein associated with UVRAG as autophagy enhancer, Protein Rubicon-like, RUBCNL

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21183-1-PBS targets C13orf18 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag15474

Product name: Recombinant human C13orf18 protein

Source: e coli.-derived, PKG

Tag: GST

Domain: 1-306 aa of BC032311

Sequence: MVSQSTVRQDSPVEPWEGISDHSGIIDGSPRLLNTDHPPCQLDIRLMRHKAVWINPQDVQQQPQDLQSQVPAAGNSGTHFVTDAASPSGPSPSCLGDSLAETTLSEDTTDSVGSASPHGSSEKSSSFSLSSTEVHMVRPGYSHRVSLPTSPGILATSPYPETDSAFFEPSHLTSAADEGAVQVSRRTISSNSFSPEVFVLPVDVEKENAHFYVADMIISAMEKMKCNILSQQQTESWSKEVSGLLGSDQPDSEMTFDTNIKQESGSSTSSYSGYEGCAVLQVSPVTETRTYHDVKEICKCDVDEFV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 chromosome 13 open reading frame 18
别名 Pacer, Protein associated with UVRAG as autophagy enhancer, Protein Rubicon-like, RUBCNL
计算分子量 662 aa, 73 kDa
观测分子量 66 kDa
GenBank蛋白编号BC032311
基因名称 C13orf18
Gene ID (NCBI) 80183
RRIDAB_10733098
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H714
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

C13orf18 (also known as Pacer), now formally designated RUBCNL (Rubicon-like autophagy enhancer), is a protein containing an EF-hand calcium-binding domain with potential transporter functions. Initially identified as a candidate tumor suppressor gene, it is frequently silenced in cervical cancer due to promoter hypermethylation. Its re-expression inhibits cervical cancer cell proliferation, suggesting tumor-suppressing activity. Furthermore, research has revealed that polymorphisms in the 3'UTR region of the C13orf18 gene are associated with amyotrophic lateral sclerosis (ALS), suggesting its potential involvement in autophagy regulation and the pathogenesis of neurodegenerative diseases.

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