• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Atomoxetine hydrochloride

CAS号

82248-59-7

分子式

C17H22ClNO

主要靶点

Dopamine Receptor|5-HT Receptor|Norepinephrine

仅限科研使用

Cat No : CM00742

Print datasheet

Synonyms

Tomoxetine|Tomoxetine hydrochloride|盐酸托莫西汀|Norepinephrine (NE) transporter|LY139603|LY-139603|LY 139603 HCl|DopamineReceptor|Dopamine Receptor|DA transporter|Atomoxetine|Atomoxetine HCl|5HTReceptor|5HT Receptor|5-HT|(R)-Tomoxetine|(R)-Tomoxetine hydrochloride

验证数据展示

  • CAS No.: 82248-59-7

    Atomoxetine hydrochloride
    CAS#: 82248-59-7

产品信息

CAS号 82248-59-7
分子式 C17H22ClNO
主要靶点 Dopamine Receptor|5-HT Receptor|Norepinephrine
主要通路 神经科学|G 蛋白偶联受体|神经科学|G 蛋白偶联受体|神经科学
分子量 291.82
纯度 99.8%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Tomoxetine|Tomoxetine hydrochloride|盐酸托莫西汀|Norepinephrine (NE) transporter|LY139603|LY-139603|LY 139603 HCl|DopamineReceptor|Dopamine Receptor|DA transporter|Atomoxetine|Atomoxetine HCl|5HTReceptor|5HT Receptor|5-HT|(R)-Tomoxetine|(R)-Tomoxetine hydrochloride

靶点活性

Dopamine transporter:1451 nM(Ki)|5-HT:77 nM(Ki)|NET:5 nM(Ki)

体内活性

Atomoxetine是去甲肾上腺素重摄取的选择性抑制剂（Ki：5 nM）,而对5-羟色胺（Ki：77 nM）和多巴胺转运蛋白（Ki：1451 nM）的选择性相对较低。

体外活性

在动物中,Atomoxetine选择性抑制肾上腺素能神经元突触前对去甲肾上腺素的摄取,且对抑郁的动物模型也有活性.在微透析研究中,Atomoxetine对5-HTEX水平无影响,但使前额皮质中细胞外去甲肾上腺素水平升高了3倍.Atomoxetine不改变伏隔核和纹状体中的DAEX和Fos,但会使PFC中DAEX浓度增加3倍、Fos增加3.7倍.

溶解度

H2O:6.9 mM;DMSO:50 mg/mL (171.34 mM)

参考文献

1.Bymaster FP, et al. Neuropsychopharmacology, 2002, 27(5), 699-711.
2.Zerbe RL, et al. J Pharmacol Exp Ther, 1985, 232(1), 139-143.
3.Wong DT, et al. J Pharmacol Exp Ther, 1982, 222(1), 61-65.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2