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(-)-Alkannin

左旋紫草素

CAS号

517-88-4

分子式

C16H16O5

主要靶点

PI3K|Apoptosis

仅限科研使用

Cat No : CM06238

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Synonyms

Alkannin|左旋紫草素|紫草素|Shikonin

验证数据展示

  • CAS No.: 517-88-4

    (-)-Alkannin
    CAS#: 517-88-4

产品信息

(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.

CAS号 517-88-4
分子式 C16H16O5
主要靶点 PI3K|Apoptosis
主要通路 PI3K/Akt/mTOR信号通路|凋亡
分子量 288.3
纯度 98.18%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 2 years
别名 Alkannin|左旋紫草素|紫草素|Shikonin

体外活性

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Cell scratch repair experiments were conducted for the determination of migration ability while transwell assay for cell invasion ability. Western blot analysis and real-time polymerase chain reaction assay were used for the detection of protein and mRNA expressions. Fifty per cent inhibitory concentration of Shikonin on MGC-803 cells was 1.854?μm. Shikonin (1?μm) inhibited significantly the adhesion, invasion and migratory ability of MGC-803 cells. Interestingly, Shikonin in the presence or absence of anti-Toll-like receptor 2 (TLR2) antibody (2?μg) and nuclear factor-kappa B (NF-κB) inhibitor MG-132 (10?μm) could decrease these ability of MGC-803 cells markedly, as well as the expression levels of matrix metalloproteinases (MMP)-2, MMP-7, TLR2 and p65 NF-κB. In addition, the co-incubation of Shikonin and anti-TLR2/MG-132 has a significant stronger activity than anti-TLR2 or MG-132 alone.

溶解度

DMSO:50 mg/mL (173.43 mM)

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2