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验证数据展示

  • IHC staining of human heart using 14745-1-AP (same clone as 14745-1-PBS)

    IHC staining of human heart using 14745-1-AP (same clone as 14745-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 14745-1-AP (ACVRL1 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

  • FC experiment of Jurkat using 14745-1-AP (same clone as 14745-1-PBS)

    FC experiment of Jurkat using 14745-1-AP (same clone as 14745-1-PBS)

    1x10^6 Jurkat cells were intracellularly stained with 0.25 ug ACVRL1 Polyclonal antibody (14745-1-AP) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG control Rabbit PolyAb (30000-0-AP) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

  • WB analysis of human placenta using 14745-1-AP (same clone as 14745-1-PBS)

    WB analysis of human placenta using 14745-1-AP (same clone as 14745-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 14745-1-AP (ACVRL1 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

  • IP experiment of Jurkat using 14745-1-AP (same clone as 14745-1-PBS)

    IP experiment of Jurkat using 14745-1-AP (same clone as 14745-1-PBS)

    IP result of anti-ACVRL1 (IP:14745-1-AP, 4ug; Detection:14745-1-AP 1:300) with Jurkat cells lysate 2400ug. This data was developed using the same antibody clone with 14745-1-PBS in a different storage buffer formulation.

ACVRL1 Polyclonal antibody, PBS Only

ACVRL1 Polyclonal Antibody for WB, IHC, FC (Intra), IP, Indirect ELISA
Cat No. 14745-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, FC (Intra), IP, Indirect ELISA

别名

ALK-1, ALK1, ALK 1, ACVRLK1, Activin receptor-like kinase 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

14745-1-PBS targets ACVRL1 in WB, IHC, FC (Intra), IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, FC (Intra), IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag6449

Product name: Recombinant human ACVRL1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 142-503 aa of BC042637

Sequence: HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 activin A receptor type II-like 1
别名 ALK-1, ALK1, ALK 1, ACVRLK1, Activin receptor-like kinase 1
计算分子量 56 kDa
观测分子量 63 kDa
GenBank蛋白编号BC042637
基因名称 ACVRL1
Gene ID (NCBI) 94
RRIDAB_2222474
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP37023
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.

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