Recombinant Human Complement C6 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 |
Not tested |
来源 | HEK293-derived Human Complement C6 protein Cys22-Ala934 (Accession# P13671) with a rabbit IgG Fc tag at the C-terminus. |
基因ID | 729 |
蛋白编号 | P13671 |
预测分子量 | 128.7 kDa |
SDS-PAGE | 120-130 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Complement C6 protein is part of the complement system and is a key component of the Membrane Attack Complex (MAC), which acts by forming pores in the plasma membrane of target cells in both natural and adaptive immune responses. The C6 protein plays a cytolytic role in the complement pathway and is involved in the immune response and cytolysis process. Together with other components of the complement cascade, it labels and removes pathogens and damaged cells. C6 proteins have been implicated in a variety of diseases, including meningitis and brucellosis. C6 complement deficiency prevents the development of diet-induced atherosclerosis. Drug development for C6 is currently underway.
参考文献:
1. Karadadas E, et al. Clin Biochem. 2020;81:15-19. 2. Lin K, et al. Blood Adv. 2020;4(9):2049-2057.