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Recombinant Mouse CD25/IL2RA protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3087

Print datasheet

Synonyms

CD25, IL-2 receptor subunit alpha, Il2r, IL-2R subunit alpha, Il2ra

验证数据展示

  • Purity of Recombinant Mouse CD25 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD25 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse CD25 protein Glu22-Lys236 (Accession# P01590) with a rabbit IgG Fc tag at the C-terminus.
基因ID 16184
蛋白编号 P01590
预测分子量 50.7 kDa
SDS-PAGE 55-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD25, the α chain of interleukin-2 receptor (IL2RA), is predominantly expressed on the surface of immune-related cells, including activated T cells, B cells, and NK cells. For cancers, CD25 is expressed at high levels in many types of hematological malignancies, but at low levels in most solid tumors. CD25 is also highly expressed in activated circulating immune cells and regulatory T cells (Tregs). CD25 is one of the non-MHC II genes associated with some autoimmune diseases such as systemic sclerosis and systemic lupus erythematosus. CD25 as a potential target for the depletion of Tregs is critical in developing new immunotherapeutic strategies.

参考文献:

1.Hinks A. et al. (2009) Arthritis Rheum. 60(1):251-257.
2.Alsahebfosoul F. et al. (2017) Mult Scler Relat Disord. 18:117-118.
3.Peng Y. et al. (2023) Int J Cancer. 152(7):1290-1303. 
4.Luo H. et al. (2023) Front Immunol. 14:1247710. 
5.Spolski R. et al. (2023) Sci Immunol. 8(89):eadi8217.