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验证数据展示

  • WB analysis of HepG2 using 83318-4-RR (same clone as 83318-4-PBS)

    WB analysis of HepG2 using 83318-4-RR (same clone as 83318-4-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 83318-4-RR (GPC1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83318-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83318-4-RR

    Affinity and Kinetic Characterization of 83318-4-RR

    Biolayer interferometry (BLl) kinetic assays of 83318-4-RR against Human GPC1 were performed. The affinity constant is 3.58 nM.

GPC1 Recombinant antibody, PBS Only

GPC1 Uni-rAbTM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA
Cat No. 83318-4-PBS

产品说明书

CloneNo. 240207G5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Cytometric bead array, Indirect ELISA

别名

glypican 1, 240207G5, FLJ38078, glypican, glypican1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

83318-4-PBS targets GPC1 in WB, Cytometric bead array, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human
免疫原 GPC1 fusion protein Eg0737 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 glypican 1
别名 glypican 1, 240207G5, FLJ38078, glypican, glypican1
计算分子量 558 aa, 62 kDa
观测分子量 61-65 kDa
GenBank蛋白编号BC051279
基因名称 GPC1
Gene ID (NCBI) 2817
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP35052
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Glypicans are a family of HSPGs that are attached to the cell membrane by a glycosyl-phosphatidylinositol anchor. Glypicans are considered to have the ability to modulate the activities of HBGFs. The expression of glypicans is regulated temporally and spatially during development, suggesting they are involved in development and morphogenesis. To date, six glypicans (GPC1 to GPC6) have been identified in mammals. GPC1 is most ubiquitously expressed in adult tissues. GPC1 promotes efficient signaling by HBGFs and plays a critical role in cell growth and differentiation. GPC1 is involved in tumorigenesis and angiogenesis, and is frequently overexpressed in several types of tumors including pancreatic carcinoma, breast cancer and glioma.