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sn-Glycero-3-phosphocholine

sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体，能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响，同时具有良好的耐受性和安全性，因此能够用于阿尔茨海默病和痴呆症的研究。

CAS号

28319-77-9

分子式

C8H20NO6P

主要靶点

Endogenous Metabolite|AChE

仅限科研使用

Cat No : CM00322

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Synonyms

Choline glycerophosphate|Alpha-GPC|Choline Alfoscerate|Glycerophosphocholine|甘磷酸胆碱|Glycerophosphorylcholine|L-α-GPC

验证数据展示

  • CAS No.: 28319-77-9

    sn-Glycero-3-phosphocholine
    CAS#: 28319-77-9

产品信息

sn-Glycero-3-phosphocholine is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimer's disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer's disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

CAS号 28319-77-9
分子式 C8H20NO6P
主要靶点 Endogenous Metabolite|AChE
主要通路 神经科学|代谢
分子量 257.22
纯度 98.53%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Choline glycerophosphate|Alpha-GPC|Choline Alfoscerate|Glycerophosphocholine|甘磷酸胆碱|Glycerophosphorylcholine|L-α-GPC

溶解度

DMSO:10mM

参考文献

1.Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.
2.Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.

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