• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

BMP signaling agonist sb4

CAS号

100874-08-6

分子式

C14H10BrNOS

主要靶点

TGF-beta/Smad

仅限科研使用

Cat No : CM06616

Print datasheet

Synonyms

agonist|BRE-luc|BMP signaling agonist sb 4|BMP signaling agonist sb4|BMP signaling agonist sb-4|bmp|bone morphogenetic protein (BMP)|PREC|Smad|SMAD|SB4|SB-4|SB 4|TGFb|TGF-b/Smad|TGFbeta/Smad|TGFbeta|TGF-beta|TGF-β/Smad|TGFβ|TGF-β Receptor|Transforming growth factor beta receptors

验证数据展示

  • CAS No.: 100874-08-6

    BMP signaling agonist sb4
    CAS#: 100874-08-6

产品信息

CAS号 100874-08-6
分子式 C14H10BrNOS
主要靶点 TGF-beta/Smad
主要通路 干细胞
分子量 320.2
纯度 99.94%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 agonist|BRE-luc|BMP signaling agonist sb 4|BMP signaling agonist sb4|BMP signaling agonist sb-4|bmp|bone morphogenetic protein (BMP)|PREC|Smad|SMAD|SB4|SB-4|SB 4|TGFb|TGF-b/Smad|TGFbeta/Smad|TGFbeta|TGF-beta|TGF-β/Smad|TGFβ|TGF-β Receptor|Transforming growth factor beta receptors

靶点活性

BMP:74 nM(EC50)

体外活性

SB4迅速激活了细胞中的BMP信号传导。通过SB4激活的BMP信号传导增加了关键第二信使(SMAD-1/5/9)的磷酸化，并且还提升了BMP信号传导中直接靶基因（DNA结合抑制因子，Id1和Id3）的表达。[1]

溶解度

DMSO:10 mg/mL (31.23 mM)

参考文献

1.Bradford S T J , Ranghini E J , Grimley E , et al. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds[J]. Journal of Biological Chemistry, 2019.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2