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p-Hydroxycinnamic acid

CAS号

7400-08-0

分子式

C9H8O3

主要靶点

Prostaglandin Receptor|Endogenous Metabolite|Thrombin

仅限科研使用

Cat No : CM01539

Print datasheet

Synonyms

Thromboxane A2 synthetase|对羟基肉桂酸|inhibit|Inhibitor|NSC 59260|p-Cumaric acid|p-Coumaric acid|p Hydroxycinnamic acid|NSC59260|NSC-59260|p-Hydroxy-cinnamic acid|pHydroxycinnamic acid|p-Hydroxycinnamic acid|PGE2|ProstaglandinReceptor|Prostaglandin Receptor|Endogenous Metabolite|EndogenousMetabolite

验证数据展示

  • CAS No.: 7400-08-0

    p-Hydroxycinnamic acid
    CAS#: 7400-08-0

产品信息

CAS号 7400-08-0
分子式 C9H8O3
主要靶点 Prostaglandin Receptor|Endogenous Metabolite|Thrombin
主要通路 代谢|G 蛋白偶联受体|免疫与炎症|蛋白酶体
分子量 164.16
纯度 99.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Thromboxane A2 synthetase|对羟基肉桂酸|inhibit|Inhibitor|NSC 59260|p-Cumaric acid|p-Coumaric acid|p Hydroxycinnamic acid|NSC59260|NSC-59260|p-Hydroxy-cinnamic acid|pHydroxycinnamic acid|p-Hydroxycinnamic acid|PGE2|ProstaglandinReceptor|Prostaglandin Receptor|Endogenous Metabolite|EndogenousMetabolite

靶点活性

TXB2:371 μM|Prostaglandin E2:126 μM

体外活性

p-Hydroxycinnamic acid（500 μM 和 1 mM）相对于基础水平分别降低了 ADP 诱导的血小板聚集（552 (SE 401) % 和 356 (SE 235) %）。p-Hydroxycinnamic acid能够调节血小板功能，这是一种模拟初级止血的剪切诱导设备。此外，p-Hydroxycinnamic acid还干预了花生四烯酸级联反应，降低了血栓素 B2 的生成和内毒素诱导的前列腺素 E2 生成（IC50 分别为 371 和 126 μM）。

溶解度

DMSO:6.25 mg/mL (38.07 mM)

参考文献

1.Luceri C, et al. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63.

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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