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dTRIM24

CAS号

2170695-14-2

分子式

C55H68N8O13S2

主要靶点

Others

仅限科研使用

Cat No : CM16140

Print datasheet

Synonyms

TRIM24|EpigeneticReaderDomain|Epigenetic Reader Domain|dTRIM24|dTRIM-24

验证数据展示

  • CAS No.: 2170695-14-2

    dTRIM24
    CAS#: 2170695-14-2

产品信息

CAS号 2170695-14-2
分子式 C55H68N8O13S2
主要靶点 Others
主要通路 表观遗传
分子量 1113.3
纯度 99.13%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 TRIM24|EpigeneticReaderDomain|Epigenetic Reader Domain|dTRIM24|dTRIM-24

体外活性

dTRIM24通过促进PARP切割从而增强凋亡，抑制生长。[1] dTRIM24是一种TRIM24溴结构域降解剂。[1] dTRIM24通过招募VHL E3泛素连接酶，引发对TRIM24的有效且选择性降解。[1]

溶解度

Ethanol:insoluble;DMSO:90.0 mg/mL (80.8 mM )

参考文献

1.Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 ; 14(4):405-412.
2.Huang JH, et al. Bioinspired PROTAC-induced macrophage fate determination alleviates atherosclerosis. 2023 ; 1-15
3.Han M, et al. Pharmacological targeting of Tripartite Motif Containing 24 for the treatment of glioblastoma. J Transl Med. 2021 ; 19(1):505.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2