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alpha-Mangostin

CAS号

6147-11-1

分子式

C24H26O6

主要靶点

Antibacterial|Virus Protease|Antifungal|Apoptosis|Reactive Oxygen Species|Dehydrogenase

仅限科研使用

Cat No : CM06902

Print datasheet

Synonyms

Fungal|inhibit|IDH1-R132H|Bacterial|Apoptosis|a-Mangostin|alpha Mangostin|alphaMangostin|alpha-Mangostin|Mangostin|Inhibitor|Reactive Oxygen Species|ReactiveOxygenSpecies|Virus Protease|VirusProtease|α-倒捻子素|α-Mangostin

验证数据展示

  • CAS No.: 6147-11-1

    alpha-Mangostin
    CAS#: 6147-11-1

产品信息

CAS号 6147-11-1
分子式 C24H26O6
主要靶点 Antibacterial|Virus Protease|Antifungal|Apoptosis|Reactive Oxygen Species|Dehydrogenase
主要通路 微生物学|代谢|NF-κB 信号通路|免疫与炎症|凋亡|微生物学|代谢|微生物学
分子量 410.46
纯度 98.22%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Fungal|inhibit|IDH1-R132H|Bacterial|Apoptosis|a-Mangostin|alpha Mangostin|alphaMangostin|alpha-Mangostin|Mangostin|Inhibitor|Reactive Oxygen Species|ReactiveOxygenSpecies|Virus Protease|VirusProtease|α-倒捻子素|α-Mangostin

靶点活性

IDH1 (mutant, R132H):2.85 μM(ki)

体内活性

Alpha-mangostin通过降低与TAA_DMSO处理相比的p53表达水平，减少了肝纤维化的风险。相较于单独使用DMSO，使用α-mangostin后，血清中的肝酶AST和ALT水平下降[4]。

体外活性

Alpha-mangostin 对 IDH1-R132H 显示出选择性抑制作用，但对 IDH1 则没有。它与竞争性地抑制 alpha-mangostin (α-KG) 绑定到 IDH1-R132H。结构-关系研究揭示了。Alpha-mangostin 选择性地促进 IDH1 (+/R132H) MCF10A 细胞中的 5-甲基胞嘧啶 (5mC) 和组蛋白 H3 三甲基化赖氨酸残基的去甲基化[1]。在用 alpha-mangostin 处理的细胞中，细胞增殖以剂量依赖性方式显著下降。Alpha-mangostin 还增加了 Bax (促凋亡)、裂解的 caspase-3、裂解的 caspase-9 以及裂解的聚(ADP-核糖)聚合酶 (PARP)[2] 的水平。Alpha-mangostin 显著抑制光诱导的视网膜感光细胞退化和 200 μM Water2 诱导的 RPE 细胞凋亡。200 μM Water2 诱导的活性氧 (ROS) 生成和光诱导的丙二醛 (MDA) 生成被 alpha-mangostin 抑制[3]。

溶解度

DMSO:45 mg/mL (109.63 mM)

细胞实验

IDH1+/+ and IDH1

参考文献

1.LEE, H., JANG, H., KIM, H., SHIN, S., CHOO, G., & PARK, Y. et al. (2016). Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.) in YD-15 tongue mucoepidermoid carcinoma cells.?International Journal Of Molecular Medicine,?37(4), 939-948. doi: 10.3892/ijmm.2016.2517

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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