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XMD8-92

CAS号

1234480-50-2

分子式

C26H30N6O3

主要靶点

Epigenetic Reader Domain|BMI-1|ERK

仅限科研使用

Cat No : CM04008

Print datasheet

Synonyms

bFGF|cancer|BMI1|BMI-1|inhibit|HMEC|Extracellular signal regulated kinases|ERK|EpigeneticReaderDomain|Epigenetic Reader Domain|leukemia|Inhibitor|promyelocytic|protein|XMD8 92|XMD892|XMD-8-92|XMD8-92

验证数据展示

  • CAS No.: 1234480-50-2

    XMD8-92
    CAS#: 1234480-50-2

产品信息

CAS号 1234480-50-2
分子式 C26H30N6O3
主要靶点 Epigenetic Reader Domain|BMI-1|ERK
主要通路 表观遗传|细胞周期|DNA 损伤和修复|MAPK 信号通路
分子量 474.55
纯度 98.19%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 bFGF|cancer|BMI1|BMI-1|inhibit|HMEC|Extracellular signal regulated kinases|ERK|EpigeneticReaderDomain|Epigenetic Reader Domain|leukemia|Inhibitor|promyelocytic|protein|XMD8 92|XMD892|XMD-8-92|XMD8-92

靶点活性

BMK1:80 nM(Kd)

体内活性

羟基红花黄色素A对肝星状细胞的活化具有抑制作用,XMD8-92可显著阻断该作用,并抑制HSYA介导的MEF2C下调。通过抑制BMK1活化,XMD8-92可显著诱导细胞中p21表达,并抑制癌细胞的增殖。

体外活性

通过对DCLK1及其几个下游靶点的显著下调,XMD8-92可抑制胰腺肿瘤异种移植物的生长.XMD8-92（50 mg/kg,i.p.）可阻断肿瘤细胞增殖以及肿瘤相关的血管生成,从而使异种移植人或同源小鼠肿瘤的生长被显著抑制.

溶解度

DMSO:19 mg/mL (40.04 mM)

参考文献

1.Yang Q, et al. Cancer Cell. 2010, 18(3), 258-267.
2.Dong H, et al. Pharm Biol. 2013. doi:10.3109/13880209.
3.Sureban SM, et al. Cancer Lett. 2014 , 351(1), 151-161.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2