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WS6

CAS号

1421227-53-3

分子式

C29H31F3N6O3

主要靶点

EGFR|IκB/IKK

仅限科研使用

Cat No : CM04733

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Synonyms

Inhibitor|IκB|IκB kinase|WS6|WS-6|WS 6|IkB|IkB/IKK|IKK|inhibit|ErbB3-Binding Protein-1 (EBP2)

验证数据展示

  • CAS No.: 1421227-53-3

    WS6
    CAS#: 1421227-53-3

产品信息

CAS号 1421227-53-3
分子式 C29H31F3N6O3
主要靶点 EGFR|IκB/IKK
主要通路 NF-κB 信号通路|血管生成|JAK/STAT 信号通路|蛋白酪氨酸激酶
分子量 568.59
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|IκB|IκB kinase|WS6|WS-6|WS 6|IkB|IkB/IKK|IKK|inhibit|ErbB3-Binding Protein-1 (EBP2)

靶点活性

Proliferation (β cells):0.28 μM

体内活性

在R7T1细胞中（EC50=0.28 μM）,WS6通过Erb3结合蛋白-1和IκB激酶信号通路作用,诱导细胞增殖。

体外活性

在切除β细胞的RIP-DTA小鼠模型中,给口服WS6（50 mg/kg ）能够β细胞增殖,从而改善糖尿病.

溶解度

DMSO:93 mg/mL (163.6 mM);Ethanol:93 mg/mL (163.6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

细胞实验

R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

参考文献

1.Shen W, et al. J Am Chem Soc. 2013, 135(5), 1669-1672.

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