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Vps34-IN-1

CAS号

1383716-33-3

分子式

C21H24ClN7O

主要靶点

PI3K|Autophagy

仅限科研使用

Cat No : CM05975

Print datasheet

Synonyms

Inhibitor|Phosphoinositide 3-kinase|PI3K|Vps34 IN 1|Vps34|Vps34IN1|Vps-34-IN-1|VPS34-IN1|Vps34-IN-1|Autophagy|inhibit

验证数据展示

  • CAS No.: 1383716-33-3

    Vps34-IN-1
    CAS#: 1383716-33-3

产品信息

CAS号 1383716-33-3
分子式 C21H24ClN7O
主要靶点 PI3K|Autophagy
主要通路 PI3K/Akt/mTOR 信号通路|自噬
分子量 425.91
纯度 97.04%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|Phosphoinositide 3-kinase|PI3K|Vps34 IN 1|Vps34|Vps34IN1|Vps-34-IN-1|VPS34-IN1|Vps34-IN-1|Autophagy|inhibit

靶点活性

VPS34:25 nM

体外活性

向细胞施用VPS34-IN1可迅速、剂量依赖性地诱导特定的PtdIns(3)P结合探针从内体膜上分散。VPS34-IN1还能在1分钟内迅速引起约50-60%的SGK3磷酸化水平下降。对于不含有PtdIns(3)P结合PX域的SGK2亚型，VPS34-IN1没有抑制作用[1]。

溶解度

Ethanol:79 mg/mL (185.5 mM);DMSO:79 mg/mL (185.5 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Bago R, et al. Biochem J. 2014 Nov 1;463(3):413-27.
2.Gao Y, Xiong J, Chu Q Z, et al. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth[J]. Journal of Cell Science. 2021, 135(5): jcs255026.
3.Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020

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