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Vitamin K1

CAS号

84-80-0

分子式

C31H46O2

主要靶点

Endogenous Metabolite|Others

仅限科研使用

Cat No : CM01572

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Synonyms

GGCX|EndogenousMetabolite|Endogenous Metabolite|Vitamin K 1|Vitamin K1|Vitamin K-1|维生素K1|叶绿醌|Osteocalcin|Phytomenadione|Phytonadione|Phyllohydroquinone|Phylloquinone|inhibit|Inhibitor

验证数据展示

  • CAS No.: 84-80-0

    Vitamin K1
    CAS#: 84-80-0

产品信息

CAS号 84-80-0
分子式 C31H46O2
主要靶点 Endogenous Metabolite|Others
主要通路 代谢
分子量 450.7
纯度 99.82%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 GGCX|EndogenousMetabolite|Endogenous Metabolite|Vitamin K 1|Vitamin K1|Vitamin K-1|维生素K1|叶绿醌|Osteocalcin|Phytomenadione|Phytonadione|Phyllohydroquinone|Phylloquinone|inhibit|Inhibitor

体内活性

在后续追踪期间，增加 Vitamin K1 饮食摄入的受试者与减少或不改变phylloquinone摄入量的受试者相比，患糖尿病的风险降低了51%[3]。维生素K补充可逆转高脂饮食引起的骨质退化，通过调节成骨细胞和破骨细胞活性，并预防高脂饮食诱导的肥胖小鼠骨质流失[4]。将Vitamin K1 应用于皮肤，已用于抑制色素沉着和消除瘀伤。局部使用 Vitamin K1 产生的效果，在创伤收缩、上皮化时间、羟脯氨酸含量以及抗张强度等参数上与对照组相比显示出显著的愈合作用[5]。

体外活性

Vitamin K1是一种由植物、绿藻和某些种类的蓝细菌专有合成的前列腺素型萘醌，它在光系统I中扮演关键的电子载体角色，并作为蛋白质二硫键形成的电子受体。Vitamin K1 在人类和其他脊椎动物中对血液凝固、骨骼和血管代谢过程是必需的。绿叶蔬菜和植物油中的Vitamin K1是人类维生素K主要的饮食来源[1]。Vitamin K1 治疗对Caco-2、HT-29和SW480细胞系表现出显著的抗增殖效果，并通过MAPK途径诱导凋亡。与此同时，多胺生物合成显著减少[2]。

溶解度

DMSO:25 mg/mL (55.47 mM)

细胞实验

Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2].

参考文献

1.Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22.
2.Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;22015:296721.
3.Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8.
4.Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13.
5.Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12.

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