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Retinyl acetate

Retinyl acetate (Vitamin A acetate) 是一种视黄醇的合成乙酸酯形式衍生物，有抗肿瘤和化学预防活性的潜能。

CAS号

127-47-9

分子式

C22H32O2

主要靶点

仅限科研使用

Cat No : CM00569

Print datasheet

Synonyms

视黄醇乙酸酯(维生素A醋酸酯)|Retinyl (Retinol) Acetate|Vitamin A acetate|Retinol acetate|视黄醇乙酸酯

验证数据展示

  • CAS No.: 127-47-9

    Retinyl acetate
    CAS#: 127-47-9

产品信息

Vitamin A is a group of unsaturated nutritional hydrocarbons, that contains retinal, retinol, retinoic acid, and several provitamins A carotenoids, among which beta-carotene is the most important.

CAS号 127-47-9
分子式 C22H32O2
主要靶点
主要通路
分子量 328.5
纯度 90.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 视黄醇乙酸酯(维生素A醋酸酯)|Retinyl (Retinol) Acetate|Vitamin A acetate|Retinol acetate|视黄醇乙酸酯

体内活性

Vitamin A acetate (VAA) (fed on an otherwise conventional diet) responds to 105 semiallogeneic cells (a suboptimal dose) in a host-versus-graft (HvG) reaction in mice, whereas mice on a conventional diet do not. [2] Vitamin A acetate can bring a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn) F1 hybrids to an end, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. [3] Vitamin A acetate-supplemented diet develops a positive skin reaction to purified protein derivative of mycobacteria in High-dose Mycobacterium bovis-infected mice, and their spleen cells show an increased IL-2 production in vitro. [4]

体外活性

Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. [1]

溶解度

DMSO:60 mg/mL (182.6 mM),Ethanol:60 mg/mL (182.6 mM),H2O:<1 mg/mL

参考文献

1.Stephensen CB, et al. Annu Rev Nutr, 2001, 21, 167-192.
2.Malkovsky M, et al. Nature, 1983 Mar, 302(5906), 338-340.
3.Malkovsky M, et al. Proc Natl Acad Sci U S A, 1985, 82(2), 536-538.
4.Colizzi V, et al. Infect Immun, 1985, 48(2), 581-583.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2