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Vacuolin-1

CAS号

351986-85-1

分子式

C26H24IN7O

主要靶点

PI3K|Autophagy

仅限科研使用

Cat No : CM05989

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Synonyms

HeLa cells|Fab1|exocytosis|Autophagy|inhibit|Inhibitor|membrane repair|PIKfyve|Vacuolin 1|Vacuolin1|Vacuolin-1

验证数据展示

  • CAS No.: 351986-85-1

    Vacuolin-1
    CAS#: 351986-85-1

产品信息

CAS号 351986-85-1
分子式 C26H24IN7O
主要靶点 PI3K|Autophagy
主要通路 PI3K/Akt/mTOR 信号通路|自噬
分子量 577.42
纯度 99.45%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 HeLa cells|Fab1|exocytosis|Autophagy|inhibit|Inhibitor|membrane repair|PIKfyve|Vacuolin 1|Vacuolin1|Vacuolin-1

体内活性

Vacuolin-1 在哺乳动物细胞中强效且可逆地抑制了自噬体与溶酶体的融合，从而诱导自噬体的积累[1]。

溶解度

DMSO:5.77 mg/mL (10 mM)

参考文献

1.Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy
2.Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun;590(11):1576-85.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2