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VU6015929

CAS号

2442597-56-8

分子式

C24H19F4N5O2

主要靶点

Discoidin Domain Receptor (DDR)

仅限科研使用

Cat No : CM03632

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Synonyms

Discoidin Domain Receptor (DDR)|Discoidin Domain Receptor|DiscoidinDomainReceptor(DDR)|DiscoidinDomainReceptor|DDR|DDR1|DDR2|VU6015929|VU-6015929|VU 6015929

验证数据展示

  • CAS No.: 2442597-56-8

    VU6015929
    CAS#: 2442597-56-8

产品信息

CAS号 2442597-56-8
分子式 C24H19F4N5O2
主要靶点 Discoidin Domain Receptor (DDR)
主要通路 蛋白酪氨酸激酶
分子量 485.43
纯度 99.63%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Discoidin Domain Receptor (DDR)|Discoidin Domain Receptor|DiscoidinDomainReceptor(DDR)|DiscoidinDomainReceptor|DDR|DDR1|DDR2|VU6015929|VU-6015929|VU 6015929

靶点活性

DDR2:7.39 nM |DDR1:4.67 nM

体外活性

VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production, suggesting DDR1 inhibition as an exciting target for antifibrotic therapy[1].

溶解度

DMSO:250 mg/mL (515.01 mM)

参考文献

1.Jeffries DE, Borza CM, Blobaum AL,et al.Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy[1].ACS Med Chem Lett. 2019 Nov 25 ;11(1):29-33.

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