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VU6012962

CAS号

2313526-86-0

分子式

C21H19F3N4O4

主要靶点

GluR

仅限科研使用

Cat No : CM05105

Print datasheet

Synonyms

VU 6012962|VU6012962|VU-6012962|Inhibitor|Metabotropic glutamate receptors|mGluR|mGlu7|inhibit

验证数据展示

  • CAS No.: 2313526-86-0

    VU6012962
    CAS#: 2313526-86-0

产品信息

CAS号 2313526-86-0
分子式 C21H19F3N4O4
主要靶点 GluR
主要通路 神经科学
分子量 448.4
纯度 98.31%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 VU 6012962|VU6012962|VU-6012962|Inhibitor|Metabotropic glutamate receptors|mGluR|mGlu7|inhibit

靶点活性

mGlu7:347 nM

体内活性

在小鼠的升高零迷宫（EZM）实验中，VU6012962（剂量1-10 mg/kg；腹腔注射；测试前60分钟）能够降低焦虑。

体外活性

与其他七种mGlu受体亚型相比，VU6012962对mGlu7具有高度选择性。

溶解度

H2O:< 0.1 mg/mL (insoluble);DMSO:125 mg/mL (278.77 mM)

参考文献

1.Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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