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VU-29

CAS号

890764-36-0

分子式

C22H16N4O3

主要靶点

GluR

仅限科研使用

Cat No : CM05104

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Synonyms

allosteric|inhibit|hippocampal|VU 29|VU29|VU-29|potentiator|rat|Inhibitor|Metabotropic glutamate receptors|mGluR|LTD|LTP

验证数据展示

  • CAS No.: 890764-36-0

    VU-29
    CAS#: 890764-36-0

产品信息

CAS号 890764-36-0
分子式 C22H16N4O3
主要靶点 GluR
主要通路 神经科学
分子量 384.39
纯度 99.63%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 allosteric|inhibit|hippocampal|VU 29|VU29|VU-29|potentiator|rat|Inhibitor|Metabotropic glutamate receptors|mGluR|LTD|LTP

靶点活性

mGluR2 (rat):1.5 μM (EC50)|mGluR5 (rat):224 nM (Ki)|mGluR5 (rat):9 nM (EC50)|mGluR1 (rat):557 nM (EC50)|mGluR4 (human):154 nM (EC50)

溶解度

DMSO:25 mg/mL (65.04 mM)

参考文献

1.Chen Y , Nong Y , Goudet C , et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.[J]. Molecular Pharmacology, 2007, 71(5):1389-1398.

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