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VU0361737

CAS号

1161205-04-4

分子式

C13H11ClN2O2

主要靶点

GluR

仅限科研使用

Cat No : CM05102

Print datasheet

Synonyms

Parkinson's|neuroprotective|Inhibitor|Metabotropic glutamate receptors|mGluR|mGluR4 (Human)|mGluR4 (Rat )|ML128|ML-128|ML 128|VU 0361737|VU0361737|VU-0361737|inhibit|disease

验证数据展示

  • CAS No.: 1161205-04-4

    VU0361737
    CAS#: 1161205-04-4

产品信息

CAS号 1161205-04-4
分子式 C13H11ClN2O2
主要靶点 GluR
主要通路 神经科学
分子量 262.69
纯度 99.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Parkinson's|neuroprotective|Inhibitor|Metabotropic glutamate receptors|mGluR|mGluR4 (Human)|mGluR4 (Rat )|ML128|ML-128|ML 128|VU 0361737|VU0361737|VU-0361737|inhibit|disease

靶点活性

mGluR4 (rat):110 nM(EC50)|mGluR4 (human):240 nM(EC50)

体内活性

VU0361737 在大鼠体内显示出高清除率(CL)，半衰期短（T1/2 20分钟），并且显著地透过血脑屏障（脑血浆比率为4.1）。[1]

体外活性

VU0361737 在mGlu1、mGlu2、mGlu3、mGlu6及mGlu7受体上无活性，并在mGlu5及mGlu8受体上表现出弱活性。[1]

溶解度

DMSO:45 mg/mL (171.3 mM)

参考文献

1.Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.
2.Engers DW, et al. J Med Chem, 2011, 54(4), 1106-1110.

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