• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

ULK1-IN-2

CAS号

2497409-01-3

分子式

C19H16BrFN4O6

主要靶点

Autophagy|Apoptosis

仅限科研使用

Cat No : CM08937

Print datasheet

Synonyms

Apoptosis|ULK1

验证数据展示

  • CAS No.: 2497409-01-3

    ULK1-IN-2
    CAS#: 2497409-01-3

产品信息

CAS号 2497409-01-3
分子式 C19H16BrFN4O6
主要靶点 Autophagy|Apoptosis
主要通路 凋亡|自噬
分子量 495.26
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Shipping with blue ice.
别名 Apoptosis|ULK1

体外活性

ULK1-IN-2（10 μM；24小时）对A549、U937、HL60、MDA-MB-468和MCF-7细胞显示出强大的抗增殖活性。在A549细胞中，通过抑制ULK1，ULK1-IN-2阻碍了自噬过程。此外，ULK1-IN-2能够以剂量依赖性方式通过线粒体途径诱导A549细胞凋亡，并以浓度依赖性方式抑制ULK1及p-ULK1ser317的表达，导致Bcl-2表达显著下降，同时增加Bax和活性形式的Caspase-3表达。[1]

溶解度

DMSO:45 mg/mL (90.86 mM)

参考文献

1.Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208:112782.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2